Open AccessRoleofgasotransmitters: nitrogen oxide and hydrogen sulfide in smool intestine of rats under cyclooxygenase and lipoxygenase inhibition
Author(s) -
Yu. O. Sklyarova,
N. V. Denysenko,
Iryna Ilkiv,
Iryna Fomenko
Publication year - 2016
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i3.6945
Subject(s) - hydrogen sulfide , cyclooxygenase , chemistry , lipoxygenase , nitrogen , oxide , biochemistry , enzyme , organic chemistry , sulfur
Inexperimentstherewerecomparedthecyclooxygenaseinhibitionbyindomethacinanddualcycloocygenaseandlipoxygenaseblockageby 4-thiazolidinonederivatives, capabletoreleasehydrogensulfidein small intestine. Itwasshownthatindomethacinwasaccompaniedbytheformationoflesions in the distal part ofsmall intestine, significantactivationofinducibleNO-synthase, thedecreaseofH2Sproduction, riseinmalonicdialdehydeconcentrationand activity of myeloperoxidase. Theadministrationof5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-4-thyoxo-thiazolidine-2-onand 2-[(4-chlor-phenyl-carbamoyl)-methyl]-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-acrylicaciddidn’tdemonstrateanulcerogenicactioninsmallintestine, thatwasprobablycausedbythereleaseofH2S from these compounds.