Open AccessRedox balance in white rats’ spleen under induced carcinogenesis
Author(s) -
І. Ya. Demkiv,
N Lisnychuk,
Yu Soroka,
O. V. Chykhyra
Publication year - 2016
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i3.6942
Subject(s) - spleen , lipid peroxidation , glutathione , antioxidant , chemistry , carcinogenesis , redox , biochemistry , pharmacology , endocrinology , medicine , enzyme , biology , organic chemistry , gene
Features of lipid peroxidation processes and antioxidant system in spleen tissue of white rats in experimental carcinogenesis and application of cytostatics were studied in experimental research. In DMH-induced cancerogenesis it was found a significant increase concentration of TBA-reactive substances and lipid hydroperoxides, decrease of antioxidant enzyme activity and reduced glutathione concentration in the examined organ tissue. The combined use of chemotherapeutic drugs increased imbalance of redox processes in spleen.