Open AccessTHE ROLE OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION FOR DEVELOPMENT PATHOGENESIS OF EXPERIMENTAL BRONCHIAL ASTHMA AND ADRENALINE MYOCARDIAL DAMAGE
Author(s) -
M. S. Reheda,
N. M. Nebelyuk M. Nebelyuk
Publication year - 2016
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i2.6673
Subject(s) - lipid peroxidation , malondialdehyde , catalase , superoxide dismutase , antioxidant , asthma , chemistry , glutathione , pathogenesis , oxidative stress , glutathione reductase , medicine , biochemistry , pharmacology , glutathione peroxidase , enzyme
The paper examined the role of lipid peroxidation (LP) and antioxidant protection in the miocardium of guinea pigs in experimental asthma (EA) in combination with adrenaline myocardial damage (AMD). Analyses were performed on the 1st, 4th, 18th and 25th day. The results showed that at all stages of the development of EA with AMD increased content of lipid peroxidation products (diene conjugates and malondialdehyde), while at the same time on the 1st and 4th day increases the activity of superoxide dismutase, catalase and glutathione reductase in the miocardium, followed by reduction in their on the 18th and 25th day.