Open AccessFORMATION OF THE ADAPTIVE RESPONSE OF THE CENTRAL NERVOU S SYSTEM IN EXPE RIMENTA L HYPOTHY ROI DISM : ONTO GENETIC ASPECTS
Author(s) -
O. H. Rodynskyi,
O. Yu. Kondratyeva,
O. Demchenko
Publication year - 2016
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i1.6195
Subject(s) - neocortex , medicine , endocrinology , hippocampus , juvenile , chemistry , linoleic acid , polyunsaturated fatty acid , fatty acid , cortex (anatomy) , serotonin , biology , biochemistry , neuroscience , genetics , receptor
In experiment on rats of three age groups – juvenile (5–6 weeks), the young (5–6 months) and old (20–24 months), there was studied the degree of formation of adaptive reactions cortex and hippocampus in a hyperthyroid condition. Increased levels of thyroid hormones (TH ) was accompanied by changes in the concentration of free fatty acids (C18:2.3) in these brain structures. In juvenile animals showed a significant increase the concentration of linoleic and linolenic acids in the cortex and hippocampus in 3.2 and 5.4 times. In young rats was also observed increase in this fraction of free fatty acids (FFA) in the neocortex to 104.8 %, in the hippocampus – 51.8 %. In older animals, as opposed to the two younger age groups, hypothyroidism caused a decrease in PUFA in the cerebral cortex of 66.4 %. These restructuring the fatty acid spectrum can modify the viscous properties of the membranes and modulatereceptor activity of serotonin mediator systems of the brain.