Open AccessChanges of lipid peroxidation and antioxidant protection in spontaneously hypertensive rats during experimental treatment by Ramipril and Candesartan
Author(s) -
Alena Marushchak,
Ye. I. Shorikov,
D. V. Shorikova,
Inga Tymofiychuk,
V. S. Haydychuk
Publication year - 2016
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2016.v0.i1.6183
Subject(s) - lipid peroxidation , candesartan , antioxidant , ramipril , chemistry , enzyme , pharmacology , medicine , endocrinology , biochemistry , angiotensin ii , receptor , blood pressure
This article talks about an investigation of the state of antioxidant-oxidation system for spontaneously hypertensive rats (SHR) using angiotensin-converting enzyme (ACE) drugs of short-term action. The study found that there is an increase of peroxidation processes while reducing the activity of antioxidant enzymes in the rats (SHR ), and there are features of regional influence of drugs above the level of lipid peroxidation and activity of antioxidant enzymes.