Age features of liver functional state in experimental chronic al coholic liver damage and correction by quercetin and L-arginine L-glutamate

The article is about the research and study of the influence of the chronic alcohol intoxication on serum biochemical data at the immature, mature аnd old rats and results with chronic alcoholic liver damage and correction of by quercetin and L-arginine L-glutamate. Chronic alcoholic liver damage is accompanied by the deviations of the main reliable biochemical data of carbohydrate, protein and lipid metabolism at the laboratory rats of the both age groups. The presence of cytolysis syndrome, cholestasis, mesenchymal inflammation confirm the development of hepatocellular insufficiency. It was established that quercetin restores protein synthetic function of the liver, and L-arginine L-glutamate significantly improved the functional state of the liver, which was manifested by decreasing of the intensity of cytolytic, cholestatic processes and of the manifestations of toxic liver damage and restoring the reparative regeneration of liver tissue at the immature, mature and old rats with chronic alcohol intoxication.