St udy of the influence of affinity purified antibodies against endocannabinoid receptor on cytokines content in the rats at experimental insulin resistance

The studies have revealed that prolonged intraperitoneal dexamethasone administration to rats against the fructose diet background is accompanied by the formation of insulin resistance syndrome. Pathological changes in cytokine (decrease of adiponectin, increase of resistin concentrations and IL‑ 6, α‑T NF as well) and hormonal (emergence hypercorticosteronemia) profiles of blood serum are observed under our experimental conditions. It was shown that a 3‑weeks administration of the studied drug (based on affinity purified antibodies against endocannabinoid receptor) substantially normalizes mentioned parameters. This is evidenced by the elevated levels of adiponectin, inhibition of resistin production and anti-inflammatory cytokines (IL‑ 6, α‑T NF), decrease of hypercorticosteronemia manifestation. The use of studied drug did not lead to changes of investigated parameters in the healthy animals, which have been keeping on a standard vivarium diet.