Open AccessIndices of free-radical oxidation and antioxidant system of rats with acute hepatitis combined with merkazolil-induced hypothyroidism
Author(s) -
O. Y. Zarichna
Publication year - 2015
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2015.v17.i3.5061
Subject(s) - lipid peroxidation , antioxidant , medicine , endocrinology , chemistry , enzyme , acute hepatitis , hepatitis , thyroid , hormone , biochemistry
In experiments on rats with modulated hypothyroidism, acute galactosamine hepatitis, acute hepatitis combined with merkazolil-induced hypothyroidism the changes in the indices of free-radical oxidation in blood and liver homogenate were studied. Results of the investigation indicate a pronounced increase of lipid peroxidation products, both in blood and in liver homogenate against the backdrop of exhaustion of the enzymatic and non-enzymatic links antioxidant protection system in animals with hypothyroidism. In case of acute galactosamine hepatitis increase of lipid peroxidation products, both in blood and in liver homogenate against the background of activation units both components of the antioxidant protection system was established. The most significant inhibition of the enzymatic and non-enzymatic links antioxidant protection system suffered rats with acute hepatitis on the background of hypothyroidism. It is concluded that failure revealed a mutual gain reflects the negative impact of acute toxic liver injury and thyroid hormone deficiency.