Open AccessAutonomous regulation of heart rate in conditions of blocking the beta 1-adrenergic receptors in associative cortex of young rats with hypoxic exposure
Author(s) -
N. M. Volkova
Publication year - 2015
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2015.v17.i3.5057
Subject(s) - receptor , endocrinology , adrenergic receptor , medicine , cerebral cortex , chemistry , heart rate , adrenergic , blood pressure , biology
The literature discusses modulation of beta-adrenergic receptors sensitivity of the cerebral cortex under changed conditions for the functioning of the body. However, very little data on the effect of the hypoxic environment to the sensitivity of beta-adrenergic receptors of the cerebral cortex in a young body, which possible to investigate in experiments on rats. The aim of the experiment was to determine the functional consequences of the exclusion of beta1-adrenergic receptors in the associative cortex in young rats after incubation in hypoxic environment under conditions of low atmospheric pressure. Blocking the beta1-adrenergic receptors in young rat’s associative cortex can significantly offset the regulatory effects on heart rate that occurred during incubation in the hypoxic environment under conditions of low atmospheric pressure. Hypoxic effect in young rats resulted in a significant decrease in sensitivity beta1-adrenergic receptors in the associative cortex.