Open AccessInterleukin 1β and TNF-α levels in the serum of patients with abdominal tuberculosis
Author(s) -
M. P. Zaletsky
Publication year - 2015
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2015.v17.i3.5053
Subject(s) - proinflammatory cytokine , inflammation , abdominal tuberculosis , tumor necrosis factor alpha , immunology , medicine , inflammatory response , tuberculosis , endocrinology , pathology
Proinflammatory cytokines are produced in response to antigen and tissue damage and stimulate the development of local inflammatory response, which is aimed at the elimination of pathogens. When local inflammation is ineffective, these mediators are produced in large quantities in tissues and activate generalized inflammatory response. The aim of the study was to determine the levels of IL‑1β, TNF‑α in patients with abdominal tuberculosis and to assess the nature of existing correlations between cytokines. In AT patients levels of IL‑1β and TNF‑α are significantly higher than the rates in healthy individuals, indicating the presence of inflammation. This fact may serve as a marker to identify hidden AT activity.