Open AccessThe influence of ademetionine on the state of prooxidantantioxidant balance in rats with glycerol-induced acute kidney failure
Author(s) -
I. I. Zamorskyi,
В. М. Драчук,
О. М. Horoshko
Publication year - 2015
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2015.v17.i3.5047
Subject(s) - ceruloplasmin , medicine , glycerol , endocrinology , chemistry , antioxidant , glutathione peroxidase , catalase , lipid peroxidation , glutathione , biochemistry , enzyme
The influence of ademetionine (heptral) on the state of prooxidant-antioxidant balance in rats’ kidneys and blood under the conditions of glycerol (rhabdomyolytic) acute renal failure was studied in the experiment. It is established, that intraperitoneal ademetionine injection in the dose of 20 mg/kg of the body weight normalizes the prooxidant-antioxidant balance indices, which manifested by a decrease of lipid and protein peroxidation intensity, increase catalase and glutathione peroxidase activity аnd increase of the ceruloplasmin level down to the indices of the control animals.