Open AccessApplication of keratoxenoimplant in the cases of experimental chemical burn of the cornea associated with hypothyroidism
Author(s) -
Zoryana Savchuk,
І. М. Кліщ
Publication year - 2015
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2015.v17.i3.5043
Subject(s) - cornea , chemical burn , medicine , sclera , chemical agents , conjunctiva , chemistry , ophthalmology , surgery , pathology , biochemical engineering , engineering
The article analyzes the efficacy of keratoimplant of pigs in rabbits with corneal chemical burns with underlying merkazolil-induced hypothyroidism. Hypothyroidism in rabbits was caused by injection of merkazolil at a dose of 10 mg/kg during 60 days. Chemical burn of the cornea was simulated by applications on the cornea of experimental animals filter paper of 5 mm in diameter soaked in a solution of 1 N sodium hydroxide (NaOH) during 30 seconds. With the purpose of surgical correction the place of burn injuries was covered with keratoxenoimplant which was sewn in 4 places (after 12, 15, 18 and 21 hours) to the sclera through the conjunctiva with the help of atraumatic needle 8/0 nylon. It was established that corneal burn injury in rabbits with hypothyroidism ran against the background of oppression of nonspecific factors of protection, more expressive growth of endogenous intoxication, depression of antioxidant protection as compared to euthyroid animals with simulated chemical burn of the cornea. Application of keratoxenoimplant contributed to the normalization of the studied parameters and faster healing of burn wounds. It was concluded that the application of keratoxenoimplant under conditions of chemical burn of the cornea positively affected the course of the burn process and promoted more rapid restoration of the integrity of the cornea.