Open AccessApplying of endogenous cardioprotection for the correction of humoral immunity in experimental diffuse cardiosclerosis in rats with different resistance to hypoxia
Author(s) -
H. S. Saturska
Publication year - 2015
Publication title -
medična ì klìnìčna himiâ
Language(s) - English
Resource type - Journals
eISSN - 2414-9934
pISSN - 2410-681X
DOI - 10.11603/mcch.2410-681x.2015.v17.i2.4873
Subject(s) - trimetazidine , hypoxia (environmental) , cardioprotection , endogeny , medicine , immunity , ischemia , cardiology , endocrinology , immunology , pharmacology , chemistry , immune system , oxygen , organic chemistry
It was studied the effect of early use of trimetazidine on changes in the Ig М, Ig G, Ig А concentration in blood serum of rats with different innate resistance to hypoxia at stages 7, 14 and 30 days of diffuse ischemic-necrotic cardiosclerosis. The comparison of the studied parameters at each stage of observation between groups treated and untreated animals was done. The results were analyzed using the latest achievements in this field. It was done the conclusion about the feasibility of early use of trimetazidine in the development of myocardial fibrosis. KEY WORDS: