Metabolic disorders in liver in late period of cranial-skeletal trauma and their correction by Thiocetam

In the conditions of cranial-skeletal trauma throughout the period of late signs of traumatic disease (14–28 days), the processes of lipidic peroxidation don’t calm down, the activity of antioxidant protection ferments remains reduced, the pro-oxidant mechanisms dominate. The use of thiocetam in 250 mg/kg dosage intraperatoneal throughout 14 days after striking of cranial-skeletal trauma essentially lowers the manifestations of free radical oxidation of the lipids, the activity of superoxide dismutase and catalase increases, the antioxidant mechanisms predominate. By the 28th day the normalization of the most of the indices occurs.