Open AccessVITAMIN D AND UROLITHIASIS IN CHILDREN
Author(s) -
Sh. A. Yusupov,
А. М. Шамсиев,
J. A. Shamsiev,
P. A. Pulotov
Publication year - 2021
Publication title -
international journal of medicine and medical research
Language(s) - English
Resource type - Journals
eISSN - 2414-9985
pISSN - 2413-6077
DOI - 10.11603/ijmmr.2413-6077.2021.1.12468
Subject(s) - allele , genotype , medicine , statistical significance , polymorphism (computer science) , incidence (geometry) , gene polymorphism , gene , population , endocrinology , genetics , biology , environmental health , physics , optics
Background. Urolithiasis is currently one of the topical issues of contemporary urology and medicine in general. This is primarily due to the high prevalence of urolithiasis; according to several population studies it ranges from 3.5 to 9.6%. At the same time, there is a steady increase in its incidence. Therefore, the matter of urolithiasis is one of the most urgent in present-day medicine.
Objectives. The aim of the research was to study the content of a polymorphic genetic marker of the vitamin D receptor gene related to development and relapse of urolithiasis in children.
Methods. The content of a polymorphic genetic marker of the vitamin D receptor gene related to development and relapse of urolithiasis in 100 children was investigated.
Results. The results of the study prove that the vitamin D receptor gene assists in revealing disorders that promote urolithiasis development.
Conclusion. Comparative analysis of the frequency of distribution of Fok1 genotypes of the vitamin D receptor gene polymorphism showed that statistical significance of the association (p=0.02) of f allele according to the dominant inheritance model (total Ff+ff genotypes) was established in the group of patients with urolithiasis compare to the corresponding indicator of the control group (63%).