Open AccessPRIMARY LARYNGEAL ASPERGILLOSIS IN AN IMMUNOCOMPETENT PATIENT
Author(s) -
KS Rajmohan,
Inam Danish Khan,
Umesh Kapoor,
Syed Asif Hashmi,
R.M. Gupta,
Sourav Sen,
G Lakshmi Prasad Rajesh Nair,
K. K. Singh,
Kundan Tandel,
Mohsin Malik
Publication year - 2020
Publication title -
international journal of medicine and medical research
Language(s) - English
Resource type - Journals
eISSN - 2414-9985
pISSN - 2413-6077
DOI - 10.11603/ijmmr.2413-6077.2019.2.10456
Subject(s) - medicine , aspergillosis , itraconazole , larynx , cord , otorhinolaryngology , vocal folds , aspergillus , mycosis , dermatology , antifungal , surgery , pathology , biology , immunology , botany
Background. Aspergillus is an inherently ubiquitous, weakly pathogenic fungus causing opportunistic infections. It is very rarely localized in the larynx, although laryngeal Aspergillosis may develop in the immunocompromised patients including those with leukaemia and severe aplastic anaemia.
Objective. The aim of the research was to explore the primary laryngeal Aspergillosis in an immunocompetent patient thru a case report.
Methods. A case report of primary laryngeal Aspergillosis in an immunocompetent patient is presented.
Results. A male patient of 40 years old, presenting with chronic worsening hoarseness, was found to have a smooth, white spheroid submucosal growth on left vocal cord with preserved bilateral cord movements on videostroboscopy. Histopathological examination of vocal cord growth revealed squamous epithelium containing septate hyphae with acute angle dichotomous branching pattern consistent with Aspergillus. Voice improved after a four-week course of oral itraconazole 200 mg/day. Post therapy follow up of 24 months was unremarkable.
Conclusions. Primary laryngeal Aspergillosis develops in the immunocompetent patients. Iatrogenic, vocal abuse, occupation and lifestyle factors may be contributory. Optimal diagnosis and management mandates a high index of suspicion.