ДИНАМІКА КЛІТИННОГО СКЛАДУ ПЕЧІНКИ ЩУРІВ ПІСЛЯ ВНУТРІШНЬОУТРОБНОГО ВВЕДЕННЯ ДЕКСАМЕТАЗОНУ В РАННЬОМУ ПІСЛЯНАТАЛЬНОМУ ПЕРІОДІ

The controversial issue in obstetrics today is the use of glucocorticoids during pregnancy, because they can have both a positive and negative impact on the processes of formation of organs and can lead to pathological conditions in the postnatal period.The aim of the study – to determine the dynamics of the cellular composition of the liver of rats after intrauterine administration of dexamethasone in the early postnatal period.Materials and Methods. The 72 laboratory rats’ liver was studied in this work. All animals were divided into 3 groups: 1 – intact, 2 – control, 3 – experimental (animals which had have injection of dexamethasone in antenatal period). Using histological, morphometric and statistical methods of research, the absolute number of cells per unit area have been calculates in two zones of hepatic lobules – central and peripheral.Results and Discussion. It was established that on the first day of life in experimental animals, the number of hepatocytes increases in comparison with control and significantly reduces the number of endothelial cells of sinusoidal capillaries and stellate macrophages. On the 14th day of life, on the contrary, the number of hepatocytes decreases with the simultaneous increase in the number of sinusoidal endothelial cells, stellate macrophages and lymphocytes.Conclusions. Thus, antenatal dexamethasone influence results in liver bring to changes in the ratio between rat’s liver cells with peaks on the first and fourteenth day of life.