Open AccessThe Art of Mesenchymal Stem Cells in Liver Fibrosis Management
Author(s) -
Dito Anurogo,
Farid Amansyah
Publication year - 2021
Publication title -
bioinformatics and biomedical research journal
Language(s) - English
Resource type - Journals
ISSN - 2620-3324
DOI - 10.11594/bbrj.03.02.03
Subject(s) - mesenchymal stem cell , liver fibrosis , fibrosis , extracellular matrix , inflammation , liver damage , liver tissue , biology , cancer research , medicine , bioinformatics , pathology , immunology , microbiology and biotechnology , endocrinology
Liver fibrogenesisis chronic tissue damage characterized by an extracellular ac-cumulation of fibrillar matrix associated with continuous degradation and remod-elling. This scientific review describes current concepts on the pathophysiology of liver fibrosis, inflammation asa fundamental concept of liver fibrosis, mechanistic concepts of liver fibrosis, the role of mesenchymal stem cells (MSC) in liver injury, the functional effects of MSC secretome, the advantages of secretome ther-apy, and the latest research developments on MSC. The role of MSCs has been proven in many liver fibrosis studies involving experimental animals. However, it still requires further research for safety and efficacy aspects.