Open AccessDetection of lipoprotein(a)- cholesterol expression in Bangladeshi adults with dyslipidemia
Author(s) -
Puja Biswas,
Fakir Md Yunus,
Tareq Hossan,
Sohel Ahmed
Publication year - 2019
Publication title -
international journal of public health science
Language(s) - English
Resource type - Journals
eISSN - 2620-4126
pISSN - 2252-8806
DOI - 10.11591/ijphs.v8i3.20060
Subject(s) - dyslipidemia , medicine , population , hypertriglyceridemia , body mass index , endocrinology , hyperlipidemia , lipoprotein , apolipoprotein b , cholesterol , triglyceride , obesity , diabetes mellitus , environmental health
Lipoprotein(a)-cholesterol (Lp(a)-C) , a low-density lipoprotein (LDL)-like particle is considered as a risk factor for cardiovascular diseases (CVDs). We aimed to investigate the association of Lp(a)-C expression with dyslipidemia among the Bangladeshi population and assess the relationship with cardiovascular risks. In this cross-sectional comparative study, a total of 180 urban males and females between ages 19-65 years were included who were enrolled in a hospital setting of Bangladesh. Participants were selected based on their total c holesterol (TC) level≥200 mg/dl, high density lipoprotein (HDL)-C<40 mg/dl, LDL-C≥140 mg/dl, and triacylglycerol (TG)≥150 mg/dl regardless of race, religion and socioeconomic status. Venous blood was collected from all participants and analyzed. Further, participants’ socio-demographics and body mass index (BMI) were collected. Expression of Lp(a)-C was detected in 22.86% patients with desirable levels (<14 mg/dL) of serum Lp(a)-C. This study suggests that the prevalence of hyperlipidemia and hypertriglyceridemia is high in the Bangladeshi population. Males were found to have lower HDL-C and higher TG than females. and, similar to other ethnic groups, a negative correlation between BMI and HDL-C was found in this population. In addition, Lp(a)-C had a positive correlation with TG which may recommend routine clinical investigation of Lp(a)-C as a biomarker for CVD risk.