Recapitulating the Pharmacological Interactions of Cetuximab with Sunitinib and Cisplatin in Head and Neck Carcinoma Cells in vitro | Zendy

Maria Dib | Zendy; Nathanil Justian | Zendy; Christian Scharf | Zendy; ChiaJung Busch | Zendy; Martin Burchardt | Zendy; Pedro Caetano-Pinto | Zendy

Open Access

Recapitulating the Pharmacological Interactions of Cetuximab with Sunitinib and Cisplatin in Head and Neck Carcinoma Cells in vitro

Author(s) -

Maria Dib,

Nathanil Justian,

Christian Scharf,

ChiaJung Busch,

Martin Burchardt,

Pedro Caetano-Pinto

Publication year - 2022

Publication title -

pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.51

H-Index - 59

eISSN - 1423-0313

pISSN - 0031-7012

DOI - 10.1159/000527082

Subject(s) - cetuximab , cisplatin , sunitinib , cancer research , head and neck cancer , head and neck squamous cell carcinoma , cancer cell , pharmacology , efflux , medicine , cancer , chemistry , colorectal cancer , chemotherapy , biochemistry

Cisplatin is extensively used in the treatment of head and neck carcinomas. Cetuximab combination therapy is employed in recurrent and metastatic settings. Sunitinib showed positive results in the treatment of head and neck carcinomas, both as monotherapy or in combination with cetuximab. Nonetheless, the mechanism governing these pharmacological interactions is largely unresolved. This study investigates the impact of cetuximab on the cytotoxicity of cisplatin and sunitinib using cells representative of head and neck carcinoma and the oral epithelium.

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