Isolation and in vitro Expansion of Regulatory T Cells from β-Thalassemia Major Kids and in vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines | Zendy

Amir Hossein Mansourabadi | Zendy; Leila Mohamed Khosroshahi | Zendy; Farshid Noorbakhsh | Zendy; Amir Ali Hamidieh | Zendy; Aliakbar Amirzargar | Zendy

Open Access

Isolation and in vitro Expansion of Regulatory T Cells from β-Thalassemia Major Kids and in vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines

Author(s) -

Amir Hossein Mansourabadi,

Leila Mohamed Khosroshahi,

Farshid Noorbakhsh,

Amir Ali Hamidieh,

Aliakbar Amirzargar

Publication year - 2022

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000526835

Subject(s) - medicine , immunology , thalassemia , immunosuppression , population , hematopoietic stem cell transplantation , transplantation , in vivo , cd28 , t cell , immune system , biology , microbiology and biotechnology , environmental health

Graft-versus-host disease (GvHD) is a life-threatening syndrome commonly associated with hematopoietic stem cell transplantation (HSCT). Preventing the incidence of GVHD after HSCT along with minimizing long-term immunosuppression is currently under investigation with regulatory T cells (Tregs). As Tregs are a low-frequency population and the yield of all memory Tregs is not sufficient for clinical application, an initial Treg expansion is essential.

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