z-logo
open-access-imgOpen Access
New Targets for Extracorporeal Blood Purification Therapies in Sepsis
Author(s) -
Céline Monard,
P. Abraham,
Antoine Schneider,
Thomas Rimmelé
Publication year - 2022
Publication title -
blood purification
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 57
eISSN - 1421-9735
pISSN - 0253-5068
DOI - 10.1159/000524973
Subject(s) - sepsis , medicine , septic shock , immune system , adjuvant , immunology , intensive care medicine , pathogen , extracorporeal , clinical trial
As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial treatment, source control, and organ support. Extracorporeal blood purification therapies have been proposed as adjuvant therapies to modulate the dysregulated inflammatory response. These therapies aim mostly at removing inflammatory mediators (cytokines) and endotoxins from the blood. However, so far, they failed to clearly demonstrate an improvement in patient survival when evaluated in randomized trials. Recently, new devices directly targeting the primary determinants of sepsis, e.g., the pathogen itself and the host immune cells, have been developed. This short review aimed at presenting new blood purification devices that have recently been developed to target pathogens and immune cells. For each, we will present the mechanism of action of the therapy and discuss the related literature.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here