Open AccessFocal Epilepsy in Individuals with Laron Syndrome
Author(s) -
Lotem Goldberg,
Zvi Laron,
Liora Kornreich,
Oded Scheuerman,
Hadassa GoldbergStern,
Dror Kraus
Publication year - 2022
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000524350
Subject(s) - epilepsy , medicine , ictal , status epilepticus , concomitant , pediatrics , psychiatry
Objective: To describe focal epilepsy in patients with Laron syndrome (LS).Methods: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. Results: We describe for the first time four patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus (SE). EEGs in all four patients showed interictal epileptiform discharges (IEDs) in the temporal regions. Three achieved long-term seizure freedom on anti-seizure medications. Conclusion: Patients with LS may be at risk of developing focal epilepsy, that seems to be unrelated to hypoglycemic episodes in childhood.