Open AccessBone Marrow Carcinomatosis in a Stage IV Breast Cancer Patient Treated by Letrozole as First-Line Endocrine Therapy
Author(s) -
Nakagawa Tsuyoshi,
Hayashi Kumiko,
Ogawa Ayumi,
Oda Goshi,
Onishi Iichiro,
Yamamoto Masahide,
Mori Mio,
Fujioka Tomoyuki,
Ishikawa Toshiaki,
Okamoto Kentaro,
Uetake Hiroyuki
Publication year - 2022
Publication title -
case reports in oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 19
ISSN - 1662-6575
DOI - 10.1159/000524152
Subject(s) - case report
Bone marrow carcinomatosis (BMC) associated with breast cancer is a rare but often difficult-to-treat condition; we report a case of a female stage IV breast cancer patient in her seventies with BMC that improved with endocrine monotherapy. The patient had hemoglobinopenia and thrombocytopenia at the time of diagnosis. The diagnosis of BMC due to estrogen receptor-positive invasive lobular carcinoma was confirmed. After transfusion of 4 units of concentrated red blood cells, endocrine treatment with letrozole improved the hematopenia. Ten months after the treatment started, bone metastases worsened, so the patient was changed to combination therapy with palbociclib and fulvestrant, after which there was no worsening of the disease.