Open AccessChronic Cutaneous Disorders Are Associated with a More Favorable Disease Presentation and Outcome in Patients with Hodgkin Lymphoma
Author(s) -
Katja Marin,
Päivi Auvinen,
Hanne Kuitunen,
Outi Kuittinen
Publication year - 2022
Publication title -
oncology research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.553
H-Index - 48
eISSN - 2296-5262
pISSN - 2296-5270
DOI - 10.1159/000522480
Subject(s) - medicine , disease , lymphoma , incidence (geometry) , epidemiology , stage (stratigraphy) , retrospective cohort study , medical record , risk factor , dermatology , paleontology , physics , optics , biology
In epidemiological studies, chronic inflammation or previous major infection have revealed to be associated with an increased risk of developing Hodgkin lymphoma (HL). The association of chronic inflammation with disease outcome is poorly defined. In this retrospective study based on 92 consecutive HL patients, we explored the incidence of previous inflammatory processes or previous major infection in newly diagnosed HL patients and their association with treatment outcome. Methods: Medical history before lymphoma diagnosis including previous infection, dental inflammation, cutaneous problems, inflammatory respiratory, gastrointestinal or musculoskeletal diseases was collected from the patient records. Also clinical HL presentation, given treatments and disease outcome were recorded. Results: 46% of HL patients had some of the studied inflammatory factor at the time of diagnosis. Chronic dermatological diseases were present in 16.3 % of patients and they were associated with an improved relapse free survival (p=0.028). Dermatological issues were also associated with early stage disease and absence of B-symptoms. Other studied inflammatory factors were not associated with any clinical variables or treatment outcome. Conclusion: Our results demonstrated that among patients with Hodgkin lymphoma, pre-existing cutaneous symptoms are associated with a limited stage disease, absence of B-symptoms and favourable prognosis.