Open AccessIncreased Risk of Liver-Related Outcomes in Chronic Hepatitis B Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis
Author(s) -
Khin Naing Thin,
Andrew Tran,
Jie Li,
Eunice Yewon Lee,
Hongli Yang,
Fajuan Rui,
Chuanli Liu,
Christopher D Stave,
Ramsey Cheung,
Mindie H. Nguyen
Publication year - 2022
Publication title -
digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.879
H-Index - 66
eISSN - 1421-9875
pISSN - 0257-2753
DOI - 10.1159/000521768
Subject(s) - medicine , odds ratio , confidence interval , metabolic syndrome , meta analysis , hepatitis b , cochrane library , chronic hepatitis , gastroenterology , web of science , subgroup analysis , immunology , obesity , virus
Chronic hepatitis B (CHB) patients with metabolic syndrome (MetS) may present increased risk of liver-related outcomes (LROs), but prior studies were limited by small sample size and/or conflicting results. Using a systematic review and meta-analytic approach, we aimed to determine the association between MetS and LROs in CHB. Methods: Two researchers independently screened studies from the PubMed, Embase, Web of Science, and Cochrane Library databases from inception to January 21, 2020, and extracted the data. Estimates were pooled using a random-effects model. Results: We screened 2,228 articles and included 10 eligible studies (18,360 CHB patients, 2,557 with MetS). MetS was significantly associated with LROs overall (odds ratio = 2.45, 95% confidence interval = 1.39–4.32) but not the individual LRO components but subgroup analyses were limited by small study numbers. Discussion/Conclusion: MetS is associated with almost 3-folds higher risk of LROs in CHB and should be considered in management decisions. However, additional studies are needed.