MDS/MPN-Unclassifiable with t(X;17)(q28;q21) and KANSL1-MTCP1/CMC4 Fusion Gene | Zendy

Peter Molony | Zendy; Adam C. Smith | Zendy; Shamini Selvarajah | Zendy; Ali Sakhdari | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

MDS/MPN-Unclassifiable with t(X;17)(q28;q21) and <b><i>KANSL1-MTCP1/CMC4</i></b> Fusion Gene

Author(s) -

Peter Molony,

Adam C. Smith,

Shamini Selvarajah,

Ali Sakhdari

Publication year - 2021

Publication title -

cytogenetic and genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.571

H-Index - 88

ISSN - 1424-8581

DOI - 10.1159/000521509

Subject(s) - biology , myeloproliferative neoplasm , genetics , myelodysplastic syndromes , myeloid , fusion gene , gene , cancer research , bone marrow , immunology , myelofibrosis

Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U) is a poorly characterized entity among overlap myeloid syndromes. Recent studies have shown heterogeneous mutational profiles in this group being able to subclassify them into entities closely related to the more well-established disorders under the umbrella term of the MDS/MPN group. Recurrent cytogenetic alterations are, nonetheless, rare in MDS/MPN-U. Here, for the first time, we report a case of MDS/MPN-U with a t(X;17)(q28;q21) chromosomal rearrangement leading to the KANSL1-MTCP1 fusion gene.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research