Open AccessGenetic Analysis of a Family with Multiple Incidences of Prostate Cancer
Author(s) -
Feng Ninghan,
Liu Fengping,
Xu Xinyu,
Wang Yang,
Sheng Qingsong,
Zhu Kuichun
Publication year - 2022
Publication title -
case reports in oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 19
ISSN - 1662-6575
DOI - 10.1159/000521122
Subject(s) - case report
A family with multiple members diagnosed with prostate cancer was identified, and genetic variants were analyzed. Three brothers were diagnosed with prostate cancer. Germline variants in BRCA1 , BRCA2 , TINF2 , and CD19 were found through next-generation DNA sequencing using a hereditary cancer panel. The BRCA1 G275D variant was present in patients, but absent in the healthy member. An ELAC2 variant was found in 1 patient. Several mutations were predicted to be deleterious by a set of computation programs. Multiple gene mutations might contribute to the overall predisposition to prostate cancer in the family. Even in cases with potentially deleterious variants in BRCA1 or BRCA2 , there could be diverse clinical manifestations.