Open AccessThe Association between Myopia and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis
Author(s) -
Wu Jian,
Hao Jie,
Du Yifan,
Cao Kai,
Lin Caixia,
Sun Runzhou,
Xie Yuan,
Wang Ningli
Publication year - 2021
Publication title -
ophthalmic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 54
eISSN - 1423-0259
pISSN - 0030-3747
DOI - 10.1159/000520468
Subject(s) - meta analysis
Background: Previous studies identified myopia as a risk factor for primary open-angle glaucoma (POAG). However, recent studies have shown different results, and the definitive relationship between myopia and POAG remains controversial. Objectives: The aim of this study was to investigate the relationship between myopia and POAG. Methods: Published articles were searched from PubMed, Embase, and Scopus databases between 1970 and 2020. A pooled analysis of the odds ratios (ORs) was performed using a random-effects model. Results: Data on the association between myopia and POAG were obtained from 16 cross-sectional studies, and the pooled OR was 2.26 (95% confidence interval [CI], 1.77–2.89, p < 0.001) in random-effects model ( I 2 = 86%; p < 0.01). For the relationship of myopia and POAG progression, data from 7 longitudinal cohort studies were included, and the pooled OR was 0.85 (95% CI, 0.73–0.99 , p = 0.042) in the random-effects model ( I 2 = 88%; p < 0.01). Conclusion: Our findings demonstrated that myopia may be a risk factor associated with POAG and a possible protective factor for POAG progression. It may be due to myopia with the presence of a lamina cribrosa defect, slowing down the visual field loss and also POAG progression. Further research for underlying mechanisms is still needed.