Open AccessMyocardial Ischemia-Reperfusion Injury: Therapeutics from a Mitochondria-Centric Perspective
Author(s) -
Mei Zhou,
Yunfeng Yu,
Xianghong Luo,
Jianzhang Wang,
Xiaodong Lan,
Pei Liu,
Yuping Feng,
Jian Wei-xiong
Publication year - 2021
Publication title -
cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 63
eISSN - 1421-9751
pISSN - 0008-6312
DOI - 10.1159/000518879
Subject(s) - reperfusion injury , mitochondrion , mitochondrial biogenesis , ischemia , medicine , autophagy , myocardial infarction , mitochondrial permeability transition pore , cardiology , bioinformatics , biology , microbiology and biotechnology , programmed cell death , apoptosis , biochemistry
Coronary arterial disease is the most common cardiovascular disease. Myocardial ischemia-reperfusion injury caused by the initial interruption of organ blood flow and subsequent restoration of organ blood flow is an important clinical problem with various cardiac reperfusion strategies after acute myocardial infarction. Even though blood flow recovery is necessary for oxygen and nutrient supply, reperfusion causes pathological sequelae that lead to the aggravation of ischemic injury. At present, although it is known that injury will occur after reperfusion, clinical treatment always focuses on immediate recanalization. Mitochondrial fusion, fission, biogenesis, autophagy, and their intricate interaction constitute an effective mitochondrial quality control system. The mitochondrial quality control system plays an important role in maintaining cell homeostasis and cell survival. The removal of damaged, aging, and dysfunctional mitochondria is mediated by mitochondrial autophagy. With the help of appropriate changes in mitochondrial dynamics, new mitochondria are produced through mitochondrial biogenesis to meet the energy needs of cells. Mitochondrial dysfunction and the resulting oxidative stress have been associated with the pathogenesis of ischemia/reperfusion (I/R) injury, which play a crucial role in the pathophysiological process of myocardial injury. This review aimed at elucidating the mitochondrial quality control system and establishing the possibility of using mitochondria as a potential therapeutic target in the treatment of I/R injuries.