Open AccessPositive Anti-GABAB Receptor Antibodies in a Patient with Hashimoto’s Thyroiditis and Bipolar Affective Disorder
Author(s) -
Sobolevskaia Polina A.,
Andreev Boris V.,
Churilov Leonid P.,
Fedotkina Tamara V.,
Gilburd Boris,
Stanova Aliya K.,
Utekhin Vladimir J.,
Shoenfeld Yehuda
Publication year - 2021
Publication title -
dubai medical journal
Language(s) - English
Resource type - Journals
ISSN - 2571-726X
DOI - 10.1159/000518554
Subject(s) - case report
A kind of autoimmune encephalitis with positive autoantibodies toward the B1 subunit of the gamma-aminobutyric acid-type B receptor is known as anti-GABABR encephalitis. It is an autoimmune brain disorder with typical manifestations of a limbic encephalitis. It can coexist with positive anti-thyroid autoantibodies. We described a 57-year-old woman who was diagnosed with a bipolar affective disorder. The patient had high titers of anti-thyroid peroxidase antibodies, and she also was positive for anti-GABABR antibodies. There is a question, if this case is a kind of comorbidity of anti-thyroid and anti-brain autoimmunity or is it a single nosological entity – a kind of Hashimoto’s encephalopathy?