N-cadherin regulates GluA1-mediated depressive-like behavior in adolescent female rat offspring following prenatal stress | Zendy

Shuya Shao | Zendy; Dan Yao | Zendy; Senya Li | Zendy; Jing Li | Zendy; Yufang Si | Zendy; Huiping Zhang | Zendy; Zhongliang Zhu | Zendy; Dongli Song | Zendy; Hui Li | Zendy

Open Access

N-cadherin regulates GluA1-mediated depressive-like behavior in adolescent female rat offspring following prenatal stress

Author(s) -

Shuya Shao,

Dan Yao,

Senya Li,

Jing Li,

Yufang Si,

Huiping Zhang,

Zhongliang Zhu,

Dongli Song,

Hui Li

Publication year - 2021

Publication title -

neuroendocrinology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000518383

Subject(s) - offspring , dentate gyrus , endocrinology , medicine , hippocampus , psychology , cnqx , ampa receptor , pregnancy , receptor , glutamate receptor , biology , genetics

The incidence of depression is twice higher in women than in men, and gender differences in the prevalence rates first emerge around puberty. Prenatal stress (PS) induces gender-dependent depressive-like behavior in adolescent offspring, but the neuro-physiological mechanisms remain unclear. Our study aimed to investigate the possible neuro-physiological mechanisms of gender-dependent depressive-like behavior in PS adolescent offspring and further explored the possibility of treating depression in adolescent female rats.

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