Open AccessN-cadherin regulates GluA1-mediated depressive-like behavior in adolescent female rat offspring following prenatal stress
Author(s) -
Shuya Shao,
Dan Yao,
Senya Li,
Jing Li,
Yufang Si,
Huiping Zhang,
Zhongliang Zhu,
Dongli Song,
Hui Li
Publication year - 2021
Publication title -
neuroendocrinology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000518383
Subject(s) - offspring , dentate gyrus , endocrinology , medicine , hippocampus , psychology , cnqx , ampa receptor , pregnancy , receptor , glutamate receptor , biology , genetics
The incidence of depression is twice higher in women than in men, and gender differences in the prevalence rates first emerge around puberty. Prenatal stress (PS) induces gender-dependent depressive-like behavior in adolescent offspring, but the neuro-physiological mechanisms remain unclear. Our study aimed to investigate the possible neuro-physiological mechanisms of gender-dependent depressive-like behavior in PS adolescent offspring and further explored the possibility of treating depression in adolescent female rats.