Open AccessPreimplantation Genetic Testing for Kidney Disease-Related Genes: A Laboratory’s Experience
Author(s) -
J Chaperon,
Nina Wemmer,
Trudy McKanna,
Dinah Clark,
Maggie Westemeyer,
Philippe Gauthier,
Yan Bai,
Jessica Coleman
Publication year - 2021
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000518253
Subject(s) - medicine , pkd1 , genetic testing , polycystic kidney disease , disease , kidney disease , pregnancy , genetics , biology
Recent literature highlights the clinical utility of genetic testing for patients with kidney disease. Genetic testing provides significant benefits for reproductive risk counseling, including the option of in vitro fertilization with preimplantation genetic testing for monogenic disease (PGT-M). PGT-M allows for a significant reduction in risk for a pregnancy affected with the familial disease. We aim to summarize our experience with PGT-M for genes with kidney involvement as either a primary or secondary feature of the disease.