Open AccessMechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury
Author(s) -
Felix C. Koehler,
Martin Richard Späth,
Karla Johanna Ruth Hoyer-Allo,
RomanUlrich Müller
Publication year - 2021
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 72
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000517733
Subject(s) - medicine , acute kidney injury , caloric theory , intensive care medicine , kidney , malnutrition , nephrology , bioinformatics , biology
Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.