Open AccessFunction of Astrocytes in Neuroprotection and Repair after Ischemic Stroke
Author(s) -
Shufen Zhang,
De-Shu Shang,
Han Shi,
Teng Wang,
Li Tian
Publication year - 2021
Publication title -
european neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 77
eISSN - 1421-9913
pISSN - 0014-3022
DOI - 10.1159/000517378
Subject(s) - neuroprotection , neuroscience , stroke (engine) , astrocyte , ischemic stroke , medicine , blood–brain barrier , central nervous system , ischemia , psychology , physics , thermodynamics
Background: Astrocytes are the most numerous cell types within the central nervous system, and many efforts have been put into determining the exact role of astrocytes in neuroprotection and repair after ischemic stroke. Although numerous studies have been done in recent years, there is still no thorough understanding of the exact function of astrocytes in the whole course of the stroke. Summary: According to the recent literature, there are many structures and factors that play important roles in the process of ischemic stroke, among which blood-brain barrier, various growth factors, gap junctions, AQP4, and glial scars have been studied most comprehensively, and all these factors are closely related to astrocytes. The role of astrocytes in ischemic stroke, therefore, can be analyzed more comprehensively. Key Message: The present review mainly summarized the current knowledge about astrocytes and their potential roles after ischemic stroke.