Open AccessRisk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts
Author(s) -
Kasia Trzcionkowska,
Floris Groenendaal,
Peter Andriessen,
Peter H. Dijk,
Frank A. M. van den Dungen,
Jacqueline Hillegersberg,
Sanne Koole,
René F. Kornelisse,
Elke van Westering-Kroon,
Jeanette S. von Lindern,
Clemens B. Meijssen,
Frank A B A Schuerman,
Katerina Steiner,
Minke W.G. van Tuyl,
Ruben S G M Witlox,
Nicoline E. SchalijDelfos,
J. Termote
Publication year - 2021
Publication title -
neonatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.399
H-Index - 84
eISSN - 1661-7819
pISSN - 1661-7800
DOI - 10.1159/000517247
Subject(s) - retinopathy of prematurity , medicine , odds ratio , gestational age , pediatrics , population , risk factor , confidence interval , childhood blindness , birth weight , prospective cohort study , pregnancy , genetics , environmental health , biology
Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP. Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Ophthalmologists provided data of screened infants, which were combined with risk factors from the national perinatal database (Perined). Clinical data and potential risk factors were compared to the first national ROP inventory (NEDROP-1, 2009). During the second period, more strict risk factor-based screening inclusion criteria were applied. Results: Of 1,287 eligible infants, 933 (72.5%) were screened for ROP and matched with the Perined data. Any ROP was found in 264 infants (28.3% of screened population, 2009: 21.9%) and severe ROP (sROP) (stage ≥3) in 41 infants (4.4%, 2009: 2.1%). The risk for any ROP is decreased with a higher GA (odds ratio [OR] 0.59 and 95% confidence interval [CI] 0.54–0.66) and increased for small for GA (SGA) (1.73, 1.11–2.62), mechanical ventilation >7 days (2.13, 1.35–3.37) and postnatal corticosteroids (2.57, 1.44–4.66). For sROP, significant factors were GA (OR 0.37 and CI 0.27–0.50), SGA (OR 5.65 and CI 2.17–14.92), postnatal corticosteroids (OR 3.81 and CI 1.72–8.40), and perforated necrotizing enterocolitis (OR 7.55 and CI 2.29–24.48). Conclusion: In the Netherlands, sROP was diagnosed more frequently since 2009. No new risk factors for ROP were determined in the present study, apart from those already included in the current screening guideline.