Open AccessWhy Do the Fetal Membranes Rupture Early after Fetoscopy? A Review
Author(s) -
Benjamin J. Amberg,
Ryan Hodges,
Karyn Rodgers,
Kelly J. Crossley,
Stuart B. Hooper,
Philip DeKoninck
Publication year - 2021
Publication title -
fetal diagnosis and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 60
eISSN - 1421-9964
pISSN - 1015-3837
DOI - 10.1159/000517151
Subject(s) - fetoscopy , medicine , fetus , fetal membrane , premature rupture of membranes , fetal surgery , obstetrics , pregnancy , surgery , placenta , prenatal diagnosis , in utero , biology , genetics
Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles’ heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.