Open AccessSleep Duration and Its Associations with Mortality and Quality of Life in Chronic Obstructive Pulmonary Disease: Results from the 2007–2015 KNAHNES
Author(s) -
So Jeong Kim,
Nakwon Kwak,
Sun Mi Choi,
Jun Young Lee,
Young Sik Park,
Chang Hoon Lee,
Sang Min Lee,
Chul Gyu Yoo,
Jae-Young Cho
Publication year - 2021
Publication title -
respiration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.264
H-Index - 81
eISSN - 1423-0356
pISSN - 0025-7931
DOI - 10.1159/000516381
Subject(s) - medicine , copd , hazard ratio , confidence interval , national health and nutrition examination survey , proportional hazards model , quality of life (healthcare) , vital capacity , body mass index , eq 5d , physical therapy , demography , disease , health related quality of life , population , lung , environmental health , lung function , nursing , sociology , diffusing capacity
Background: While extreme sleep duration negatively affects mortality and health-related quality of life (HRQOL) in general populations, the relationship remains uncertain in patients with chronic obstructive pulmonary disease (COPD). Objectives: To evaluate the association between sleep duration and mortality and HRQOL in patients with COPD. Methods: We analyzed 3,349 participants with COPD enrolled in the 2007–2015 Korea National Health and Nutrition Examination Survey (KNHANES). Participants aged 40 years or older with a smoking history and prebronchodilator forced expiratory volume in 1 s/forced vital capacity (FEV 1 /FVC) <0.7 were eligible. The participants were categorized as short sleepers (<6 h), 6–8 h, and long sleepers (>8) according to self-reported sleep duration. The outcome variables were all-cause mortality and HRQOL. HRQOL was measured using the European Quality of Life-5 Dimensions (EQ-5D) index. Results: During a median of 6.5 years, 386 (11.5%) participants died. In unadjusted Cox regression analysis, short sleepers with COPD had an increased risk of death (hazard ratio, 1.35; 95% confidence interval [CI]: 1.07–1.71). However, this association was not significant after adjusting for sociodemographic factors, BMI, FEV 1 , and comorbidities. In unadjusted and adjusted multiple linear regression, short sleepers had significantly worse HRQOL. The adjusted means of the EQ-5D index were 0.88 (95% CI: 0.87–0.89) for short sleepers, 0.90 (95% CI: 0.90–0.91) for 6- to 8-h sleepers, and 0.89 (95% CI: 0.87–0.91) for long sleepers ( p = 0.01). Conclusions: In patients with COPD, sleep duration was not associated with all-cause mortality. However, short sleep duration was significantly associated with worse HRQOL.