Open AccessPrognostic Analysis and Risk Factors Associated with Fetal Ventriculomegaly
Author(s) -
Qiming Li,
Hongzhan Liao,
Wenbo Wang,
Shi-Yi Zeng,
XianSheng Qiu,
Ke Shuai,
Jing Xiao,
Qinghua Li,
Xuewei Xia,
Yong Li
Publication year - 2021
Publication title -
pediatric neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 72
eISSN - 1423-0305
pISSN - 1016-2291
DOI - 10.1159/000516378
Subject(s) - medicine , logistic regression , ventriculomegaly , fetus , multivariate analysis , gestational age , retrospective cohort study , hydrocephalus , pregnancy , obstetrics , case control study , pediatrics , surgery , biology , genetics
Background: This study aimed to investigate the clinical outcome and related risk factors of fetal lateral ventriculomegaly (VM). Methods: A retrospective analysis was performed on 255 cases diagnosed as fetal VM. Prenatal imaging examination was carried out. The pregnancy outcomes were investigated through follow-up. According to the prognosis of children, they were divided into case group and control group. Multivariate logistic regression was used to analyze the factors influencing the prognosis of hydrocephalus. Results: After excluding the cases with either loss of follow-up or incomplete information, 102 cases were followed up. Twelve cases with poor prognosis were set as the case group. According to the maternal age, gestational age, gender of children, and follow-up time, 3 cases were selected from the other 90 cases for each child in the case group, respectively, and selected as the control group. Paired comparative analysis was performed on 48 cases. Using prognosis as a dependent variable, multivariate logistic regression analysis of the statistically significant factors indicated that the change speed of width ratio (CSWR) and maximum lateral ventricular width (MW) were associated with fetal prognosis. Conclusions: Our results suggested that CSWR and MW may have the value of predicting fetal prognosis.