Successful Cord Blood Transplantation for Idiopathic CD4+ Lymphocytopenia | Zendy

Ken Yamamoto | Zendy; Yuho Najima | Zendy; Hiroko Iizuka | Zendy; Yuka Harada | Zendy; Daichi Sadato | Zendy; Akinori Kanai | Zendy; Hirotaka Matsui | Zendy; Kyoko Inamoto | Zendy; Junichi Mukae | Zendy; Naoki Shingai | Zendy; Takashi Toya | Zendy; Aiko Igarashi | Zendy; Hiroaki Shimizu | Zendy; Takeshi Kobayashi | Zendy; Kazuhiko Kakihana | Zendy; Hisashi Sakamaki | Zendy; Kazuteru Ohashi | Zendy; Hironori Harada | Zendy

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Successful Cord Blood Transplantation for Idiopathic CD4<sup>+</sup> Lymphocytopenia

Author(s) -

Ken Yamamoto,

Yuho Najima,

Hiroko Iizuka,

Yuka Harada,

Daichi Sadato,

Akinori Kanai,

Hirotaka Matsui,

Kyoko Inamoto,

Junichi Mukae,

Naoki Shingai,

Takashi Toya,

Aiko Igarashi,

Hiroaki Shimizu,

Takeshi Kobayashi,

Kazuhiko Kakihana,

Hisashi Sakamaki,

Kazuteru Ohashi,

Hironori Harada

Publication year - 2021

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000516347

Subject(s) - lymphocytopenia , medicine , fludarabine , regimen , transplantation , cord blood , immunology , surgery , gastroenterology , lymphocyte , cyclophosphamide , chemotherapy

Idiopathic CD4 + lymphocytopenia (ICL) is the depletion of CD4 + lymphocytes to <300 cells/mm 3 without human immunodeficiency virus infection or other causes of lymphocytopenia. ICL causes fatal infections; its etiology remains unclear and it lacks consensus regarding therapeutic options. We report the first patient with ICL who had a successful clinical course following a cord blood transplant (CBT). A 45-year-old woman was diagnosed with ICL and underwent partial hepatectomy for an abscess caused by the Mycobacterium avium complex. No specific gene alterations were detected through next generation sequencing-based evaluation. Following a reduced-intensity conditioning (RIC) regimen consisting of fludarabine, busulfan, and 4 Gy total body irradiation, a single-unit CBT was performed. Neutrophils were engrafted on day +14. CD4 + lymphocyte counts increased to over 300 cells/mm 3 on day +436. After 75 months, she was alive without any sequelae. CBT with an RIC regimen could be a curable treatment option for ICL.

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