Open AccessHair Growth in a Patient with Alopecia Areata on Tocilizumab
Author(s) -
Chloe J. Walker,
Kelly Flanagan,
James T. Pathoulas,
Isabel Pupo Wiss,
Maryanne M. Senna
Publication year - 2021
Publication title -
skin appendage disorders
Language(s) - English
Resource type - Journals
eISSN - 2296-9195
pISSN - 2296-9160
DOI - 10.1159/000516300
Subject(s) - alopecia areata , tocilizumab , medicine , hair growth , concomitant , monoclonal , dermatology , monoclonal antibody , immunology , antibody , disease , physiology
Introduction: Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. Case Presentation: Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. Discussion: Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.