Open AccessFertility Preservation for Prepubertal Patients at Risk of Infertility: Present Status and Future Perspectives
Author(s) -
Valentina Pampanini,
Jasmin Hassan,
Elizabeth Oliver,
Jan-Bernd Stukenborg,
Pauliina Damdimopoulou,
Kirsi Jahnukainen
Publication year - 2020
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000516087
Subject(s) - fertility preservation , fertility , infertility , medicine , gynecology , ovarian tissue cryopreservation , oocyte cryopreservation , population , intensive care medicine , cryopreservation , female infertility , pregnancy , environmental health , biology , genetics , embryo , microbiology and biotechnology
The increasing cure rate of cancer has led to a vast population of survivors having to face the late adverse effects of oncological treatments, with fertility impairment being one of the most sensitive issues for patients. Different options to preserve the fertility of adult patients are routinely used in clinical practice. However, fertility preservation strategies for prepubertal patients at risk of infertility are limited to the cryopreservation of immature gonadal tissue. In recent decades, many research efforts have been focused on the future use of cryopreserved gonadal tissue. This review discusses the common status of fertility preservation measures for pediatric patients undergoing gonadotoxic treatment, focusing especially on the challenges that remain to be solved in order to implement this fundamental service.