Clinical Efficacy of Ponatinib in Philadelphia-Positive T-Cell Acute Lymphoblastic Leukemia with Extramedullary Involvement | Zendy

Gianluca Cristiano | Zendy; Jacopo Nanni | Zendy; Chiara Sartor | Zendy; Sarah Parisi | Zendy; Giovanni Marconi | Zendy; Francesco Barbato | Zendy; Mario Arpinati | Zendy; Francesca Bonifazi | Zendy; Antonio Curti | Zendy; Michèle Cavo | Zendy; Stefania Paolini | Zendy; Cristina Papayannidis | Zendy

Open Access

Clinical Efficacy of Ponatinib in Philadelphia-Positive T-Cell Acute Lymphoblastic Leukemia with Extramedullary Involvement

Author(s) -

Gianluca Cristiano,

Jacopo Nanni,

Chiara Sartor,

Sarah Parisi,

Giovanni Marconi,

Francesco Barbato,

Mario Arpinati,

Francesca Bonifazi,

Antonio Curti,

Michèle Cavo,

Stefania Paolini,

Cristina Papayannidis

Publication year - 2021

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000516003

Subject(s) - ponatinib , medicine , philadelphia chromosome , myeloid leukemia , hematopoietic stem cell transplantation , chromosomal translocation , leukemia , cancer research , transplantation , chemotherapy , blinatumomab , tyrosine kinase inhibitor , acute lymphocytic leukemia , lymphoblastic leukemia , oncology , dasatinib , imatinib , biology , cancer , genetics , gene

T-cell acute lymphoblastic leukemia (T-ALL) is a rare entity in the adult acute leukemia setting. Translocation (9;22)(q34;q11) and BCR-ABL1 rearrangement are occasionally found in T-ALL and have been reported in no more than 100 cases in the literature (most of which are chronic myeloid leukemia blast crisis). Here, we report the remarkable effectiveness of third-generation tyrosine-kinase inhibitor ponatinib in obtaining hematological and metabolic remission, in a patient with Philadelphia chromosome-positive de novo T-ALL and outcomes of a therapeutic strategy containing chemotherapy intensification, nelarabine, and allogeneic hematopoietic stem cell transplantation.

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