Open AccessThe Emerging Role of Circular RNAs in Cerebral Vascular Disorders
Author(s) -
Wei Liu,
Yan Gao
Publication year - 2021
Publication title -
european neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 77
eISSN - 1421-9913
pISSN - 0014-3022
DOI - 10.1159/000515807
Subject(s) - circular rna , microrna , biology , mechanism (biology) , neuroscience , computational biology , pathogenesis , bioinformatics , gene , genetics , immunology , philosophy , epistemology
Background: Circular RNAs (circRNAs) are covalently closed circular noncoding RNAs that are expressed in various life forms. CircRNAs have many characteristics, such as structural stability and tissue-specific expression that contribute to their role as a microRNA (sponge in gene regulation. Summary: Recent evidence suggests that circRNAs play an important role in the pathogenesis of cerebrovascular diseases (CVDs); however, the exact mechanism remains controversial. CircRNAs that are related to CVDs have great clinical significance. Key Messages: The present review provides an overview of the general biology of circRNAs, their relevant regulatory mechanisms, and their role in the pathophysiology of CVDs.