Open AccessThe Role of Interleukin-27 in Atherosclerosis: A Contemporary Review
Author(s) -
Mehrian Jafarizade,
Farima Kahe,
Sadaf Sharfaei,
Kaveh Momenzadeh,
Anmol Pitliya,
Farbod Zahedi Tajrishi,
Preeti Singh,
Gerald Chi
Publication year - 2021
Publication title -
cardiology
Language(s) - English
Resource type - Journals
eISSN - 1421-9751
pISSN - 0008-6312
DOI - 10.1159/000515359
Subject(s) - pathogenesis , medicine , inflammation , myocardial infarction , neovascularization , immunology , endothelium , downregulation and upregulation , interleukin , angiogenesis , cytokine , cardiology , cancer research , biology , biochemistry , gene
Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis.