Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis | Zendy

Domenico Benvenuto | Zendy; Francesca Benedetti | Zendy; Ayşe Banu Demir | Zendy; Massimo Ciccozzi | Zendy; Davide Zella | Zendy

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Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis

Author(s) -

Domenico Benvenuto,

Francesca Benedetti,

Ayşe Banu Demir,

Massimo Ciccozzi,

Davide Zella

Publication year - 2021

Publication title -

chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 54

eISSN - 1421-9794

pISSN - 0009-3157

DOI - 10.1159/000515342

Subject(s) - coronavirus , virology , mutation , covid-19 , genome , virus , biology , pandemic , medicine , disease , genetics , gene , infectious disease (medical specialty) , outbreak , pathology

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy. Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID. Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein. Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.

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