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Background:   Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting &amp;#x3e;220 countries around the world, with &amp;#x3e;80 million cases registered and &amp;#x3e;1.8 million deaths.   Objective:   As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy.   Methods:   DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID.   Results:   In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein.   Conclusion:   The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.

Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis