Animal Hosts and Experimental Models of SARS-CoV-2 Infection | Zendy

Cristina Parolin | Zendy; Sara Virtuoso | Zendy; Marta Giovanetti | Zendy; Silvia Angeletti | Zendy; Massimo Ciccozzi | Zendy; Alessândra Borsetti | Zendy

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Animal Hosts and Experimental Models of SARS-CoV-2 Infection

Author(s) -

Cristina Parolin,

Sara Virtuoso,

Marta Giovanetti,

Silvia Angeletti,

Massimo Ciccozzi,

Alessândra Borsetti

Publication year - 2021

Publication title -

chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 54

eISSN - 1421-9794

pISSN - 0009-3157

DOI - 10.1159/000515341

Subject(s) - coronavirus , outbreak , covid-19 , transmission (telecommunications) , biology , betacoronavirus , virology , natural reservoir , disease reservoir , animal model , severe acute respiratory syndrome coronavirus , pandemic , disease , medicine , infectious disease (medical specialty) , pathology , endocrinology , electrical engineering , engineering

Viruses arise through cross-species transmission and can cause potentially fatal diseases in humans. This is the case of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which recently appeared in Wuhan, China, and rapidly spread worldwide, causing the outbreak of coronavirus disease 2019 (COVID-19) and posing a global health emergency. Sequence analysis and epidemiological investigations suggest that the most likely original source of SARS-CoV-2 is a spillover from an animal reservoir, probably bats, that infected humans either directly or through intermediate animal hosts. The role of animals as reservoirs and natural hosts in SARS-CoV-2 has to be explored, and animal models for COVID-19 are needed as well to be evaluated for countermeasures against SARS-CoV-2 infection. Experimental cells, tissues, and animal models that are currently being used and developed in COVID-19 research will be presented.

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