Analysis of YAG Laser-Induced Damage in Intraocular Lenses: Characterization of Optical and Surface Properties of YAG Shots

Purpose: To assess differences in neodymium:yttrium aluminum garnet (Nd:YAG)-induced defects in hydrophilic and hydrophobic intraocular lenses (IOLs) and describe optical and surface properties of YAG shots/pitting. Describing and measuring the iatrogenic produced defects should achieve higher awareness on this topic and change the mindset of such a trivial procedure to be proceeded with more caution and calmness in the future. Materials: Twelve IOLs from different manufacturers made of hydrophilic and hydrophobic materials were evaluated before and after treatment with the Nd:YAG laser. Microscopy and environmental scanning electron microscopic (ESEM) images were used to visually analyze the defects. Additionally, wavefront measurements were taken for power mapping and Raman spectroscopy was performed. Vertical and horizontal dimensions of the defects were analyzed and compared, and Raman line scans assessed the changes in the chemical structure in the defect area of the IOL. Results: Microscopically, pitting of the surface could be observed in both lens types. Defects in hydrophobic lenses appeared bigger and were visible with less magnification than in hydrophilic lenses. Similar results were obtained with ESEM images where the defects in hydrophobic IOLs seemed to be frayed while defects in hydrophilic IOLs were of circular shape. Raman spectroscopy revealed deeper defects in hydrophobic lenses. Vertical dimensions of the defects were statistically significant ( p = 0.036) and greater in hydrophobic materials while horizontal dimensions did not reach significance ( p = 0.056). The area of chemical changes was greater than the visible defect area and smaller in hydrophilic than that in hydrophobic materials. Conclusion: Nd:YAG seems to have greater impact on hydrophobic IOL materials as that damage was greater and more frayed than that in hydrophilic materials. Moreover, there seems to be larger, distinctive damage area in IOLs (with chemical changes in the material) than that is visually recognizable. Therefore, a very cautious approach is recommended when performing capsulotomy, as defects in the surface structure can occur. This might come along with problems in quality of vision in monofocal and primarily premium IOLs (multifocal, enhanced depth of focus, and toric IOLs), dependent on the size, dimension, and position in the IOL. YAG capsulotomy should not be considered trivial but should be carried out with precision and without time pressure, just like surgery itself.