Open AccessThe Impact of Nail Psoriasis and Treatment on Quality of Life: A Systematic Review
Author(s) -
Claire Stewart,
Leah Algu,
Rakhshan Kamran,
Cameron F. Leveille,
Khizar Abid,
Charlene Rae,
Shari R. Lipner
Publication year - 2021
Publication title -
skin appendage disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.773
H-Index - 13
eISSN - 2296-9195
pISSN - 2296-9160
DOI - 10.1159/000512688
Subject(s) - psoriasis , medicine , quality of life (healthcare) , dermatology life quality index , adalimumab , psoriasis area and severity index , patient reported outcome , nail (fastener) , dermatology , severity of illness , nail disease , physical therapy , disease , materials science , nursing , metallurgy
At least 80% of patients with psoriasis will have nail involvement during their lifetimes. Understanding quality of life (QoL) impact of this condition and associated treatments is of utmost importance. Study objectives were to review the available literature describing patient-reported QoL outcomes in nail psoriasis and relationship with disease severity and treatment. A literature search was performed for English-language articles published prior to August 1, 2020. Articles were included in the review if primary data and validated patient-reported outcome measures assessing QoL were presented, and nail involvement was specifically examined. Fifteen studies were included in the final analysis. Patients with nail psoriasis had higher Psoriasis Area Severity Index and Dermatology Life Quality Index scores than those with psoriasis without nail involvement. The largest percent improvement in QoL score was associated with adalimumab. Studies investigating topicals, intralesionals, and systemic treatments were excluded since only biologic studies utilized validated patient-reported outcome measures. This review affirms that nail psoriasis is physically and emotionally distressing, warranting prompt treatment. Increased efforts are needed to address the impact of treatment on patient QoL using validated outcome measures that assess cosmetic, physical, and social problems.