Open AccessCerebral Hyperperfusion Syndrome and Related Conditions
Author(s) -
Montserrat González Delgado,
Julien Bogousslavsky
Publication year - 2020
Publication title -
european neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 77
eISSN - 1421-9913
pISSN - 0014-3022
DOI - 10.1159/000511307
Subject(s) - reversible cerebral vasoconstriction syndrome , cerebral blood flow , medicine , vasoconstriction , cerebral autoregulation , posterior reversible encephalopathy syndrome , cerebral edema , encephalopathy , cerebral perfusion pressure , anesthesia , pathophysiology , cerebral circulation , autoregulation , cardiology , neuroscience , psychology , blood pressure , magnetic resonance imaging , radiology
Cerebral vasoconstriction is a normal physiological response under determined conditions to preserve a normal cerebral blood flow. However, there are several syndromes, with impaired cerebral autoregulation and cerebral vasoconstriction, not related with infection or inflammation, which share the same radiological and clinical presentation. We review here the cerebral hyperperfusion syndrome and related conditions such as hypertensive encephalopathy, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome. These syndromes might share the same pathophysiological mechanism with endothelial damage, cerebral vasoconstriction, blood-brain barrier disturbance, cerebral edema, and, occasionally, intracerebral hemorrhage, with fatal cases described in all. Despite knowledge of these syndromes, they still remain unknown to us. Why these entities present in some patients and not in others goes further than the actual understanding of these diseases. We have to consider that a genetic susceptibility and molecular disturbances may be involved. Thus, more studies are needed in order to better characterize such syndromes.